Scientific Guidance on COVID-19 caused by SARS-CoV-2
The Severe Acute Respiratory Syndrome Coronavirus-2 causes the Coronavirus Disease 2019 pandemic. Coronaviruses are enveloped single-stranded RNA viruses, spreads primarily via respiratory droplets and diagnosed by nucleic and serological tests. Clinically progresses from dry cough to respiratory distress and cytokine storm, incubates in 5 days and at risk are old patients with comorbidity. Therapies include acetaminophen for mildly ill and antiviral inhibitors such as remdesivir, alongside passive/plasma and active/vaccine immunization.
SARS-CoV-2 hijacks lungs’ alveoli with its spike proteins, triggers inflammation and fluid accumulation. Immune system responds with cytokine storm. Acute Respiratory Distress Syndrome (ARDS) and Systematic Inflammatory Response Syndrome (SIRS) may occur resulting in septic shock and multi-organ failure.